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Adrenomedullin and Proadrenomudullin N‐Terminal 20 Peptide (PAMP) are Present in Human Colonic Epithelia and Exert an Antimicrobial Effect
Author(s) -
Marutsuka K.,
Nawa Y.,
Asada Y.,
Hara S.,
Kitamura K.,
Eto T.,
Sumiyoshi A.
Publication year - 2001
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/eph8602250
Subject(s) - adrenomedullin , peptide , antimicrobial , vasoactive intestinal peptide , beta defensin , antimicrobial peptides , chemistry , microbiology and biotechnology , pharmacology , medicine , biology , biochemistry , neuropeptide , receptor
The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene‐related peptide, proadrenomedullin N‐terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose‐dependent antimicrobial activity against E. coli. The results suggest that the novel vasoactive peptides AM and PAMP play an important role in mucosal defence.