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Effects of Pinealectomy on Glucagon Responsiveness to Hypoglycaemia Induced by Insulin Injections in Fed Rats
Author(s) -
Kosa Erzsebet,
Maurel Daniel,
Siaud Philippe
Publication year - 2001
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/eph8602205
Subject(s) - glucagon , pinealectomy , medicine , endocrinology , insulin , insulin response , melatonin , pancreatic hormone , chemistry , plasma glucose , pineal gland , insulin resistance
The glucagon response to insulin‐induced hypoglycaemia was tested in rats that had been pinealectomised (Px), pinealectomised and fitted with melatonin implants (Px + MLT), or sham‐operated (SO). The glucagon response to hypoglycaemia observed in SO rats (216 ± 27 pg ml −1 at baseline versus 397 ± 35 pg ml −1 at the hypoglycaemic peak, mean ± S.D.) was stronger than that in Px rats (180 ± 37 pg ml −1 and 229 ± 21 pg ml −1 , respectively) and weaker than that in Px + MLT rats (256 ± 19 pg ml −1 and 516 ± 11 pg ml −1 , respectively). Our data indicate that the capacity to release glucagon during insulin‐induced hypoglycaemia is altered in pinealectomised rats.