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The Effect of Acidosis on the Ecg of the Rat Heart
Author(s) -
Aberra A.,
Komukai K.,
Howarth F. C.,
Orchard C. H.
Publication year - 2001
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/eph8602051
Subject(s) - acidosis , medicine , cardiology , heart rate , qrs complex , anesthesia , blood pressure
We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P‐R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis‐induced changes in transmitter release from severed autonomic nerve terminals within the heart.