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Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes
Author(s) -
GilakDalasm Mohadeseh,
Peeri Maghsoud,
Azarbayjani Mohammad Ali
Publication year - 2021
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/ep089501
Subject(s) - anhedonia , type 2 diabetes , medicine , endocrinology , depression (economics) , inflammation , diabetes mellitus , proinflammatory cytokine , tumor necrosis factor alpha , physical exercise , animal models of depression , antidepressant , dopamine , hippocampus , economics , macroeconomics
New FindingsWhat is the central question of this study? Can swimming exercise decrease depression‐like behaviour and inflammation in type 2 diabetic mice?What is the main finding and its importance? Swimming exercise decreased depression‐like behaviour by reducing inflammation in type 2 diabetic mice. Swimming exercise might be useful for the treatment of depression‐related disorders in patients with type 2 diabetes.Abstract Clinical and experimental studies have shown that type 2 diabetes is associated with depression‐related disorders. Inflammation has been identified as a common mechanism in both type 2 diabetes and depression. Several studies have suggested that swimming exercise might be able to reduce depression‐related symptoms. The present study aimed to explore whether swimming exercise can decrease depression‐like behaviour in type 2 diabetic mice. To induce type 2 diabetes, male C57BL6 mice were treated with a high‐fat diet and streptozocin. Type 2 diabetic animals were subjected to swimming exercise for 4 weeks. Then, depression‐like behaviours were evaluated by sucrose preference, novelty‐suppressed feeding, social interaction and tail suspension tests. We also measured levels of glucose, insulin and pro‐inflammatory cytokines such as interleukin‐1β and tumour necrosis factor‐α in the serum of animals. The results indicated that type 2 diabetes significantly increased anhedonia‐ and depression‐like behaviours in mice. We also found significant increases in glucose, insulin and inflammatory cytokines in diabetic mice. Moreover, swimming exercise reduced anhedonia‐ and depression‐like behaviour in type 2 diabetic mice. Swimming exercise also decreased glucose and inflammatory cytokines in the serum of mice with type 2 diabetes. Collectively, this study demonstrates that swimming exercise decreased depression‐like behaviour by reducing inflammation in type 2 diabetic mice. Further clinical studies are needed to validate these findings in patients with type 2 diabetes.