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Breath holding as an example of extreme hypoventilation: experimental testing of a new model describing alveolar gas pathways
Author(s) -
Taboni Anna,
Fagoni Nazzareno,
Fontolliet Timothée,
Grasso Gabriele Simone,
Moia Christian,
Vinetti Giovanni,
Ferretti Guido
Publication year - 2020
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/ep088977
Subject(s) - supine position , hypoventilation , ventilation (architecture) , pulmonary gas pressures , control of respiration , partial pressure , chemistry , oxygen , anesthesia , mechanics , respiratory system , thermodynamics , physics , medicine , organic chemistry
New FindingsWhat is the central question of this study ? We modelled the alveolar pathway during breath holding on the hypothesis that it follows a hypoventilation loop on the O 2 –CO 2 diagram.What is the main finding and its importance? Validation of the model was possible within the range of alveolar gas compositions compatible with consciousness. Within this range, the experimental data were compatible with the proposed model. The model and its characteristics might allow predictions of alveolar gas composition whenever the alveolar ventilation goes to zero; for example, static and dynamic breath holding at the surface or during ventilation/intubation failure in anaesthesia.Abstract According to the hypothesis that alveolar partial pressures of O 2 and CO 2 during breath holding (BH) should vary following a hypoventilation loop, we modelled the alveolar gas pathways during BH on the O 2 –CO 2 diagram and tested it experimentally during ambient air and pure oxygen breathing. In air, the model was constructed using the inspired and alveolar partial pressures of O 2 ( P I O 2and P A O 2, respectively) and CO 2 ( P IC O 2and P AC O 2, respectively) and the steady‐state values of the pre‐BH respiratory exchange ratio (RER). In pure oxygen, the model respected the constraint ofP AC O 2= − P A O 2+ P I O 2. To test this, 12 subjects performed several BHs of increasing duration and one maximal BH at rest and during exercise (30 W cycling supine), while breathing air or pure oxygen. We measured gas flows, P A O 2and P AC O 2before and at the end of all BHs. Measured data were fitted through the model. In air, P I O 2 = 150 ± 1 mmHg and P IC O 2 = 0.3 ± 0.0 mmHg, both at rest and at 30 W. Before BH, steady‐state RER was 0.83 ± 0.16 at rest and 0.77 ± 0.14 at 30 W; P A O 2 = 107 ± 7 mmHg at rest and 102 ± 8 mmHg at 30 W; and P AC O 2 = 36 ± 4 mmHg at rest and 38 ± 3 mmHg at 30 W. By model fitting, we computed the RER during the early phase of BH: 0.10 [95% confidence interval (95% CI) = 0.08–0.12] at rest and 0.13 (95% CI = 0.11–0.15) at 30 W. In oxygen, model fitting provided P I O 2: 692 (95% CI = 688–696) mmHg at rest and 693 (95% CI = 689–698) mmHg at 30 W. The experimental data are compatible with the proposed model, within its physiological range.