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Ageing augments nicotinic and adenosine triphosphate‐induced, but not muscarinic, cutaneous vasodilatation in women
Author(s) -
Fujii Naoto,
McGarr Gregory W.,
Sigal Ronald J.,
Boulay Pierre,
Nishiyasu Takeshi,
Kenny Glen P.
Publication year - 2019
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/ep088144
Subject(s) - vasodilation , nicotinic agonist , medicine , endocrinology , muscarinic acetylcholine receptor , methacholine , agonist , ageing , nicotine , adenosine , chemistry , receptor , respiratory disease , lung
New FindingsWhat is the central question of this study? Does ageing augment muscarinic, nicotinic and/or ATP‐mediated cutaneous vasodilatation in women?What is the main finding and its importance? Ageing augments nicotinic and ATP‐induced, but not muscarinic, cutaneous vasodilatation in women. This will stimulate future studies assessing the pathophysiological significance of the augmented microvascular responsiveness in older women compared to their young counterparts.Abstract We previously reported that ageing attenuates adenosine triphosphate (ATP)‐induced, but not muscarinic and nicotinic, cutaneous vasodilatation in men, and that ageing may augment cutaneous vascular responses in women. In the present study, we evaluated the hypothesis that ageing augments muscarinic, nicotinic and/or ATP‐mediated cutaneous vasodilatation in healthy women. In 11 young (23 ± 5 years) and 11 older (60 ± 8 years) women, cutaneous vascular conductance was evaluated at three forearm skin sites that were perfused with (1) methacholine (muscarinic receptor agonist, 5 doses: 0.0125, 0.25, 5, 100, 2000 m m ), (2) nicotine (nicotinic receptor agonist, 5 doses: 1.2, 3.6, 11, 33, 100 m m ), or (3) ATP (purinergic receptor agonist, 5 doses: 0.03, 0.3, 3, 30, 300 m m ). Each agonist was administered for 25 min per dose. Methacholine‐induced increases in cutaneous vascular conductance were not different between groups at all doses (all P > 0.05). However, a nicotine‐induced elevation in cutaneous vascular conductance at the lowest concentration (1.2 m m ) was greater in older vs . young women (43 ± 15 vs . 26 ± 10%max, P = 0.04). ATP‐induced increases in cutaneous vascular conductance at moderate and high doses (3 and 30 m m ) were also greater in older relative to young women (3 m m , 44 ± 11 vs . 28 ± 10%max, P = 0.02; 30 m m , 83 ± 14 vs . 64 ± 17%max, P = 0.05). Therefore, ageing augments nicotinic and ATP‐induced, but not muscarinic, cutaneous vasodilatation in women.