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Therapeutic effect of oligomeric proanthocyanidin in cuprizone‐induced demyelination
Author(s) -
Wang Qing,
Wang Jing,
Yang Zhichao,
Sui Ruoxuan,
Miao Qiang,
Li Yanhua,
Yu Jiezhong,
Liu Chunyun,
Zhang Guangxian,
Xiao Baoguo,
Ma Cungen
Publication year - 2019
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/ep087480
Subject(s) - remyelination , myelin , multiple sclerosis , microglia , oligodendrocyte , myelin oligodendrocyte glycoprotein , white matter , neurodegeneration , immunology , medicine , chemistry , biology , inflammation , neuroscience , experimental autoimmune encephalomyelitis , pathology , central nervous system , magnetic resonance imaging , disease , radiology
New FindingsWhat is the central question of this study? Oligomeric proanthocyanidin has the capacity to alleviate abnormalities in neurological functioning. However, whether oligomeric proanthocyanidin can reduce the progression of demyelination or promote remyelination in demyelinating diseases remains unknown.What is the main finding and its importance? Oligomeric proanthocyanidin can improve cuprizone‐induced demyelination by inhibiting immune cell infiltration, reversing overactivated microglia, decreasing the inflammatory cytokines secreted by inflammatory cells and decreasing the production of myelin oligodendrocyte glycoprotein 35–55 ‐specific antibody in the brain.Abstract Demyelinating diseases of the CNS, including multiple sclerosis, neuromyelitis optica and acute disseminated encephalomylitis, are characterized by recurrent primary demyelination–remyelination and progressive neurodegeneration. In the present study, we investigated the therapeutic effect of oligomeric proanthocyanidin (OPC), the most effective component of grape seed extract, in cuprizone‐fed C57BL/6 mice, a classic demyelination–remyelination model. Our results showed that OPC attenuated abnormal behaviour, reduced demyelination and increased expression of myelin basic protein and expression of O4 + oligodendrocytes in the corpus callosum. Oligomeric proanthocyanidin also reduced the numbers of B and T cells, activated microglia in the corpus callosum and inhibited secretion of inflammatory factors. Furthermore, concentrations of myelin oligodendrocyte glycoprotein‐specific antibodies were significantly reduced in serum and brain homogenates after OPC treatment. Together, these results demonstrate a potent therapeutic effect for OPC in cuprizone‐mediated demyelination and clearly highlight multiple effects of this natural product in attenuating myelin‐specific autoantibodies and the inflammatory microenvironment in the brain.