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Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation
Author(s) -
McLay Kaitlin M.,
Fontana Federico Y.,
Nederveen Josh P.,
Guida Federico F.,
Paterson Donald H.,
Pogliaghi Silvia,
Murias Juan M.
Publication year - 2015
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/ep085406
Subject(s) - saturation (graph theory) , spectroscopy , oxygen , oxygen saturation , infrared , infrared spectroscopy , nuclear magnetic resonance , analytical chemistry (journal) , chemistry , materials science , biophysics , medicine , biology , environmental chemistry , mathematics , physics , optics , organic chemistry , quantum mechanics , combinatorics
New FindingsWhat is the central question of this study? Can the near‐infrared spectroscopy (NIRS)‐derived reperfusion rate (slope 2) of tissue oxygen saturation ( S tO 2 ) be correlated with flow‐mediated dilation (FMD), the commonly used method to assess vascular endothelial function?What is the main finding and its importance? The present data were able to establish a correlation between the reperfusion rate of S tO 2 and percentage FMD in healthy young men. These data suggest that NIRS‐derived slope 2 S tO 2 can be used as a measure of vascular endothelial function.Vascular impairments at the macro‐ and microcirculatory levels are associated with increased risk for cardiovascular disease. Flow‐mediated dilation (FMD) is currently the most widely used method for non‐invasive assessment of vascular endothelial function. Recently, near‐infrared spectroscopy (NIRS)‐derived measures of tissue oxygen saturation ( S tO 2 ) have been used to characterize the dynamic response of local tissue perfusion to a brief period of ischaemia. The purpose of the present study was to establish correlations between the reperfusion rate of S tO 2 and FMD. Ultrasound‐derived FMD was quantified after 5 min of distal cuff occlusion of the popliteal artery in 20 healthy young men (26 ± 3 years old). Triplicate measurements of end‐diastolic arterial diameter were made every 15 s after cuff release, and FMD response was calculated as the greatest percentage change in diameter from baseline (%FMD). The S tO 2 was measured using NIRS throughout the duration of each test. Two consecutive FMD tests were performed, separated by 30 min of rest, and were averaged for %FMD and S tO 2 . The %FMD was significantly correlated with the reperfusion slope of S tO 2 after cuff release (slope 2 S tO 2 ; r = 0.63, P = 0.003). In conclusion, the present study established a correlation between slope 2 S tO 2 and %FMD in healthy young men. These data suggest that NIRS‐derived slope 2 S tO 2 can be used as a measure of vascular endothelial function.