Open AccessEFFECT OF MYOCARDIAL INFARCTION ON SPLEEN AND KIDNEY OF ISOPRENALINE-INDUCED MYOCARDIAL INJURY RAT MODEL
Author(s) -
Shafreena Shaukat Ali,
Nur Hafiqah Rozalei,
Siti Fatimah Azaharah Mohamed,
Wei Boon Yap,
Satirah Zainalabidin
Publication year - 2019
Publication title -
jurnal teknologi/jurnal teknologi
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.191
H-Index - 22
eISSN - 2180-3722
pISSN - 0127-9696
DOI - 10.11113/jt.v81.12987
Subject(s) - spleen , medicine , myocardial infarction , lactate dehydrogenase , kidney , inflammation , myeloperoxidase , endocrinology , isoprenaline , creatine kinase , cardiology , biology , enzyme , stimulation , biochemistry
Myocardial infarction (MI)-associated inflammation is crucial for post-infarct healing. However, unregulated inflammation may lead to unnecessary systemic inflammation, and affect other organs. This study investigated the effects of MI on spleen and kidneys over early time-points (2 and 7 days) in isoprenaline-induced MI rat model. MI was evident by elevated levels of cardiac injury marker, troponin T, and lactate dehydrogenase (LDH). MI rats showed significant upregulation of myeloperoxidase (MPO) activity at day-2 post infarct while kidney MPO activity remained unaffected. Kidney function test revealed only slightly increased plasma urea at day-2 post MI with no changes in plasma creatine at both time-points. Histological observation on the spleen showed disorganization of spleen structure at day-2 post MI while the kidney structures were preserved at both time-points. In conclusion, although MI-associated damages in the spleen were seen at day-2 post infarct, it had no impact on the kidney structures at both time-points.