Open AccessFABRICATION OF POLY(LACTIC-CO-GLYCOLIC ACID)/CALCIUM PHOSPHATE BONE CEMENT COMPOSITE: SYNTHESIZATION OF CALCIUM PHOSPHATE FROM CRAB SHELLS
Author(s) -
Mohammad Redzuan Abdul Hanan,
Ahmad Kafrawi Nasution,
Rafaqat Hussain,
Syafiqah Saidin
Publication year - 2018
Publication title -
jurnal teknologi/jurnal teknologi
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.191
H-Index - 22
eISSN - 2180-3722
pISSN - 0127-9696
DOI - 10.11113/jt.v80.11525
Subject(s) - plga , materials science , simulated body fluid , glycolic acid , composite number , calcium , chemical engineering , apatite , cement , nanocomposite , bone cement , nanoparticle , composite material , contact angle , lactic acid , nanotechnology , metallurgy , scanning electron microscope , biology , bacteria , engineering , genetics
Crab shells are waste product, rich with calcium compound. Calcium element is often used as a material for bone scaffold due to its bioactive and biodegradation properties. In this study, calcium phosphate (CaP) nanoparticles were synthesized from crab shells through a wet chemical route. The CaP nanoparticles were then sintered and mixed with poly(lactic-co-glycolic acid) (PLGA) to form a bone cement composite. The mixture was casted in a cylinder shape and it was characterized through ATR-FTIR, XRD, FESEM, contact angle and DSC analyses. The CaP pellet and the CaP/PLGA bone cement composite were then subjected to in vitro simulated body fluid (SBF) bioactivity test. The CaP/PLGA bone cement composite was found to have a composition of crystal CaP and PLGA with a tolerable glass transition state, suitable to be used in a physiological environment. The CaP nanoparticles were agglomerated on the 3D interconnected surface of PLGA. The hydrophobicity of the CaP was increased (66.94%) with the addition of PLGA as a binder matrix where this composite has induced the formation of apatite layer. This bioactive property is crucial in fabricating a bone substitute material as it can promotes cell penetration, attachment and proliferation..