Premium
Zoonotic infection by Cryptosporidium fayeri IVgA10G1T1R1 in a Western Australian human
Author(s) -
Braima Kamil,
Zahedi Alireza,
Oskam Charlotte,
Austen Jill,
Egan Siobhon,
Reid Simon,
Ryan Una
Publication year - 2021
Publication title -
zoonoses and public health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.87
H-Index - 65
eISSN - 1863-2378
pISSN - 1863-1959
DOI - 10.1111/zph.12806
Subject(s) - cryptosporidium , biology , nitazoxanide , 18s ribosomal rna , molecular epidemiology , zoonosis , parasite hosting , parasitology , ribosomal rna , virology , zoology , microbiology and biotechnology , genetics , feces , immunology , gene , genotype , world wide web , computer science
In the present study, a 37‐year‐old immunosuppressed female in Western Australia (WA) was identified as positive for Cryptosporidium by microscopy and treated with nitazoxanide. Molecular analyses at the 18S ribosomal RNA (18S) and 60 kDa glycoprotein ( gp60 ) loci identified C . fayeri subtype IVgA10G1T1R1, which had previously been identified in western grey kangaroos ( Macropus fuliginosus ) in WA. Next generation sequencing (NGS) of the gp60 locus confirmed the absence of mixed infections with other Cryptosporidium species. This is only the second report of C . fayeri in a human host highlighting the zoonotic potential of this wildlife‐associated species. Routine diagnosis using molecular methods in laboratories is required to better understand the diversity and epidemiology of Cryptosporidium parasite.