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Rural habitat as risk factor for hepatitis E virus seroconversion in HIV ‐infected patients: A prospective longitudinal study
Author(s) -
RiveroJuarez A.,
CuencaLopez F.,
MartinezPeinado A.,
Camacho A.,
Real L. M.,
Frias M.,
Gordon A.,
Cantisán S.,
TorreCisneros J.,
Pineda J. A.,
Rivero A.
Publication year - 2017
Publication title -
zoonoses and public health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.87
H-Index - 65
eISSN - 1863-2378
pISSN - 1863-1959
DOI - 10.1111/zph.12347
Subject(s) - seroconversion , hepatitis e virus , medicine , incidence (geometry) , prospective cohort study , population , virology , antibody , immunology , environmental health , biology , biochemistry , physics , genotype , optics , gene
Summary Our objective was to determine the incidence and clinical manifestations of acute hepatitis E virus ( HEV ) in HIV ‐infected patients. A prospective longitudinal study including HIV ‐infected HEV ‐seronegative patients was conducted; HEV seroconversion (to IgG and/or IgM) was the main outcome variable. All patients were tested for HEV antibodies every 3–6 months. For patients who developed HEV seroconversion, a data collection protocol was followed to identify associated clinical manifestations and analytical alterations. A total of 627 patients (89.9%) were followed during a median of 11.96 months ( IQR : 8.52–14.52 months) and formed the study population. Forty‐one patients developed detectable anti‐ HEV antibodies (7.2 cases per 100 patients/year). Our study found a high incidence of HEV in HIV ‐infected patients in southern Spain strongly associated with a rural habitat.