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Differences in platelet aggregometers to study platelet function and coagulation dysregulation in xenotransplantation
Author(s) -
Isidan Abdulkadir,
Chen Angela M.,
Saglam Kutay,
Yilmaz Sezai,
Zhang Wenjun,
Li Ping,
Ekser Burcin
Publication year - 2020
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1111/xen.12645
Subject(s) - xenotransplantation , thromboelastometry , coagulation , thromboelastography , platelet , immunology , medicine , transplantation , platelet activation
Xenotransplantation (ie, cross‐species transplantation) using genetically engineered pig organs could be a limitless source to solve the shortage of organs and tissues worldwide. However, despite prolonged survival in preclinical pig‐to‐nonhuman primate xenotransplantation trials, interspecies coagulation dysregulation remains to be overcome in order to achieve continuous long‐term success. Different platelet aggregometry methods have been previously used to study the coagulation dysregulation with wild‐type and genetically engineered pig cells, including the impact of possible treatment options. Among these methods, while thromboelastography and rotational thromboelastometry measure the change in viscoelasticity, optical aggregometry measures the change in opacity. Recently, impedance aggregometry has been used to measure changes in platelet aggregation in electrical conductance, providing more information to our understanding of coagulation dysregulation in xenotransplantation compared to previous methods. The present study reviews the merits and differences of the above‐mentioned platelet aggregometers in xenotransplantation research.