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Ascites formation accompanied by portal vein thrombosis after porcine islet xenotransplantation via the portal vein in Rhesus macaque ( Macaca mulatta )
Author(s) -
Kim JongMin,
Shin JunSeop,
Han Sungyoung,
Min ByoungHoon,
Jeong Won Young,
Lee Ga Eul,
Kim Min Sun,
Kwon Seeun,
Chung Hyunwoo,
Kang Hee Jung,
Park ChungGyu
Publication year - 2018
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1111/xen.12460
Subject(s) - xenotransplantation , medicine , islet , portal vein thrombosis , transplantation , portal vein , ascites , thrombosis , liver transplantation , inferior vena cava , surgery , insulin
Abstract Pig‐to‐nonhuman primate ( NHP ) islet transplantation has been widely conducted as a preclinical xenotransplantation model prior to human clinical trial. Portal vein thrombosis is one of the complications associated with islet infusion through the portal vein into the liver. Here, we briefly report severe case of ascites formation accompanied by portal vein thrombi after pig‐to‐ NHP islet xenotransplantation in a rhesus monkey. Meticulous prophylactic treatment such as continuous heparin infusion should be implemented to prevent portal vein thrombi in pig‐to‐ NHP islet transplantation models.