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The 2017 IXA Presidential Lecture: Recent developments in xenotransplantation
Author(s) -
Cowan Peter J.
Publication year - 2018
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1111/xen.12416
Subject(s) - xenotransplantation , crispr , immunosuppression , endogenous retrovirus , medicine , biology , transplantation , immunology , genetics , genome , gene
The last few years have seen significant progress in xenotransplantation. Porcine xenograft survival in preclinical models continues to improve, accompanied by the adjustment of immunosuppression to more clinically realistic levels. The rapid uptake of CRISPR/Cas9 technology has accelerated the generation of new knock‐in and knockout pigs, including animals null for the endogenous retrovirus PERV. This brief review presents a personal view of recent developments in the field.