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A highly reproducible cervical cuff technique for rat‐to‐mouse heterotopic heart xenotransplantation
Author(s) -
Li Yaguang,
Xie Baiyi,
Zhu Maoshu,
Li Xianguo,
Du Feifei,
Li Yanping,
Li Minghui,
Yuan Qian,
Hua Jianyu,
Xue Mengjiao,
Wang Zhenzhen,
Xia Junjie,
Qi Zhongquan
Publication year - 2017
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1111/xen.12331
Subject(s) - xenotransplantation , economic shortage , transplantation , medicine , heart transplantation , immunology , cuff , surgery , linguistics , philosophy , government (linguistics)
Xenotransplantation is an effective way to solve the problem of donor shortage in clinical transplantation. However, clinical use of xenotransplantation is currently limited due to immunological challenges such as acute vascular rejection and cell‐mediated rejection. To finally surpass this immunological barrier, more preclinical research is needed into the molecular mechanisms of rejection and the possible effects of new immunosuppressants. Our aim was to create a refined, highly reproducible protocol to establish the most suitable rat‐to‐mouse heterotopic heart transplantation model using the cuff technique.