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Fibroblast‐like synoviocytes: Role in synovial fibrosis associated with osteoarthritis
Author(s) -
Maglaviceanu Anca,
Wu Brian,
Kapoor Mohit
Publication year - 2021
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12939
Subject(s) - myofibroblast , extracellular matrix , fibroblast , osteoarthritis , fibrosis , synovial membrane , microbiology and biotechnology , population , pathogenesis , extracellular , chemistry , cancer research , pathology , immunology , medicine , biology , arthritis , in vitro , biochemistry , alternative medicine , environmental health
The synovial membrane undergoes a variety of structural changes throughout the pathogenesis of osteoarthritis (OA), including the development of fibrosis. Fibroblast‐like synoviocytes (FLS) are a heterogenous cell population of the synovium that are suggested to drive the fibrotic response, but the exact mechanisms associated with their activation in OA remain unclear. Once activated, FLS are suggested to acquire a myofibroblast‐like phenotype that drives fibrogenesis through excessive extracellular matrix (ECM) component deposition and an enhanced contractile function. In this review, we define FLS in the synovium, discuss how select extracellular or endogenous factors potentially induce their activation in OA, and describe how the activity of myofibroblast‐like cells affects the structure of the synovial membrane.