Premium
The preclinical and clinical implications of fetal adnexa derived mesenchymal stromal cells in wound healing therapy
Author(s) -
Mankuzhy Pratheesh D.,
Ramesh Sreekumar T.,
Thirupathi Yasotha,
Mohandas Ponny S.,
Chandra Vikash,
Sharma Taru Guttula
Publication year - 2021
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12911
Subject(s) - wound healing , mesenchymal stem cell , homing (biology) , medicine , cell therapy , stromal cell , immunology , pathology , stem cell , biology , microbiology and biotechnology , ecology
Mesenchymal stromal cells (MSCs) isolated from fetal adnexa namely amniotic membrane/epithelium, amniotic fluid and umbilical cord have hogged the limelight in recent times, as a proposed alternative to MSCs from conventional sources. These cells which are identified as being in a developmentally primitive state have many advantages, the most important being the non‐invasive nature of their isolation procedures, absence of ethical concerns, proliferation potential, differentiation abilities and low immunogenicity. In the present review, we are focusing on the potential preclinical and clinical applications of different cell types of fetal adnexa, in wound healing therapy. We also discuss the isolation‐culture methods, cell surface marker expression, multi‐lineage differentiation abilities, immune‐modulatory capabilities and their homing property. Different mechanisms involved in the wound healing process and the role of stromal cells in therapeutic wound healing are highlighted. Further, we summarize the findings of the cell delivery systems in skin lesion models and paracrine functions of their secretome in the wound healing process. Overall, this holistic review outlines the research findings of fetal adnexa derived MSCs, their usefulness in wound healing therapy in human as well as in veterinary medicine.