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Does vitamin D deficiency predispose to keloids via dysregulation of koebnerisin ( S100A15 )? A case‐control study
Author(s) -
El Hadidi Heba H.,
Sobhi Rehab M.,
Nada Ahmed M.,
AbdelGhaffar Mariam M. M.,
Shaker Olfat G.,
ElKalioby Mona
Publication year - 2021
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12894
Subject(s) - keloid , vitamin d and neurology , medicine , biopsy , inflammation , wound healing , fibrosis , receptor , skin biopsy , pathology , endocrinology , immunology
Keloids result from uncontrolled inflammation and fibrosis during wound healing. Vitamin D can regulate skin proliferation and inflammation. Fibroblasts are vitamin D‐responsive target cells and are source of koebnerisin (an antimicrobial peptide released during inflammation and wound healing). This study aimed to assess the levels and correlations between the serum and tissue 25‐Hydroxyvitamin D, tissue vitamin D receptors, and serum and tissue koebnerisin (S100A15) in patients with keloids. Nineteen patients with keloids and 20 matched controls were recruited. From each keloid patient, a serum sample and two biopsies were taken from the keloid (lesional) (Tissue A) and from normal skin (non‐lesional) (Tissue B). From controls, a serum sample and a tissue biopsy from normal skin were taken. Serum and tissue 25‐Hydroxyvitamin D, tissue vitamin D receptors, and serum and tissue koebnerisin were measured in retrieved samples using ELISA. Results revealed a significantly lower serum 25‐Hydroxyvitamin D, tissue vitamin D receptors, as well as, serum and tissue koebnerisin in keloid patients compared to controls. Tissue 25‐Hydroxyvitamin D was significantly lower in keloidal skin biopsy (Tissue A) compared to non‐lesional normal skin biopsy (Tissue B). Tissue koebnerisin showed a significant positive correlation with tissue vitamin D receptors, and a significant negative correlation with tissue 25‐Hydroxyvitamin D. There was a significant negative correlation between serum 25‐Hydroxyvitamin D and duration of keloid. Accordingly, low serum and tissue 25‐Hydroxyvitamin D and deficient tissue vitamin D receptors contribute to the pathogenesis of keloids. This can be partly mediated by dysregulation of the antimicrobial peptide; koebnerisin. Artificial antimicrobial peptides and koebnerisin‐modifying drugs, for example, vitamin D and TNF‐α inhibitors can have a role in keloid prevention and treatment.