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A review of epigenetic regulation in wound healing: Implications for the future of wound care
Author(s) -
Lewis Christopher J.,
Stevenson Andrew,
Fear Mark W.,
Wood Fiona M.
Publication year - 2020
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12838
Subject(s) - epigenetics , chromatin , histone , chromatin remodeling , biology , microbiology and biotechnology , wound healing , dna methylation , regulation of gene expression , epigenetic regulation of neurogenesis , computational biology , gene expression , bioinformatics , gene , genetics
Abstract Epigenetic regulatory mechanisms are essential for maintaining skin homeostasis and aid in the processes of wound healing. The nucleus co‐ordinates gene expression using epigenetic regulatory mechanisms based on distinct chromatin structural states and their remodeling. These include DNA methylation and hydroxymethylation, post‐translational histone modifications, ATP‐dependent chromatin remodeling and higher‐order chromatin structure and 3D genome organization. Epigenetic pathways play a key role in co‐ordinating the behavior and activity of the multitude of cell types seen during skin repair, and research is now focusing on how wound healing can be modulated by altering the activity of certain reparative genes. Herein, we aim to highlight recent advances in understanding epigenetic regulatory mechanisms, with particular reference to those involved in keratinocyte and fibroblast biology. We also propose future directions for exploration of epigenetic mechanisms, and their potential clinical applications in acute wound care.