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A review on different methods to increase the efficiency of mesenchymal stem cell‐based wound therapy
Author(s) -
Shojaei Fereshteh,
Rahmati Shima,
Banitalebi Dehkordi Mehdi
Publication year - 2019
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12749
Subject(s) - mesenchymal stem cell , wound healing , angiogenesis , granulation tissue , paracrine signalling , regenerative medicine , progenitor cell , cell , stem cell , cell therapy , medicine , cancer research , immunology , microbiology and biotechnology , chemistry , biology , pathology , biochemistry , receptor
Mesenchymal stem cells (MSCs) accelerate wound healing but the harsh environment of wound site limits the engraftment, retention, and survival rate of transplanted cells. There are multiple approaches that amplify the therapeutic potential of MSCs. The MSCs derived from medical waste material, provide comparable regenerative abilities compared to traditional sources. The application of different scaffolds increases MSC delivery and migration into the wound. The spheroid culture of MSC increases the paracrine effects of the entrapped cells and the secretion of pro‐angiogenic and anti‐inflammatory cytokines. The MSC pretreating and preconditioning enhances the cell migration, proliferation, and survival rate, which lead to higher angiogenesis, re‐epithelialization, wound closure, and granulation tissue formation. Moreover, genetic modification has been performed in order to increase MSC angiogenesis, differentiation potential, as well as the cell life span. Herein, we review the results of aforementioned approaches and provide information accommodating to the continued development of MSC‐based wound therapy in the future.