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Wound healing activity of Streptocaulon juventas root ethanolic extract
Author(s) -
Nguyen Minh Can,
Le Dinh To,
Kamei Kaeko,
Dang Thi Phuong Thao
Publication year - 2017
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12599
Subject(s) - granulation tissue , wound healing , angiogenesis , traditional medicine , in vitro , chemistry , antimicrobial , antioxidant , pharmacology , biology , medicine , biochemistry , immunology , cancer research , organic chemistry
Streptocaulon juventas is a well‐known plant that has antimicrobial activity, in vitro antiplasmodial activity, anti‐proliferative activity, and antioxidant activity. In this study, we showed experimental evidence that proved that S. juventas root ethanolic extract has wound healing activities. First, in a mouse excision wound model, S. juventas root ethanolic extract at a dose of 100 mg/kg/day significantly reduced the wound closure time. After 7 days, the wound granulation tissue in mice treated with the extract exhibited a 2.3‐fold decrease in inflammatory cells, a 1.7‐fold increase in fibroblasts and enhanced angiogenesis. Molecular analysis also revealed that after wounds were treated with S. juventas root ethanolic extract, TNF‐α and NF‐κB1 gene expression were down‐regulated by 4.7 and 3.7 times, respectively. In contrast, TGF‐β1 and VEGF gene expression were up‐regulated by 1.9 and 6.5 times, respectively. Taken together, our experimental data strongly show that the ethanolic extract from S. juventas root displays remarkable wound healing activity.