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Platelet‐rich plasma for resistant oral erosions of pemphigus vulgaris: A pilot study
Author(s) -
ELKomy Mohamed Hussein Medhat,
Hassan Akmal Saad,
Raheem Heba Mohammed Abdel,
Doss Sally Sameh,
ELKaliouby Mona,
Saleh Noha Adly,
Saleh Marwah Adly
Publication year - 2015
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12363
Subject(s) - pemphigus vulgaris , medicine , platelet rich plasma , pemphigus , oral lichen planus , dermatology , mastication , oral mucosa , recurrent aphthous stomatitis , platelet , gastroenterology , stomatitis , dentistry , pathology
Oral erosions and ulcers of pemphigus vulgaris (PV) are a debilitating condition that is usually difficult to treat. The wound healing properties of platelet‐rich plasma (PRP) encouraged us to evaluate its usefulness in treatment of non‐healing oral PV lesions. Seven patients with chronic oral PV, resistant to conventional therapy, were treated with weekly to monthly injections of PRP of affected mucosal membranes. All recruits reported improvement in pain and mastication and 6 of 7 patients had an improvement in pemphigus disease area index scores with PRP treatment. PRP injections seems to accelerate the healing process and decrease the pain and eating discomfort associated with the oral erosions and ulcers induced by PV.