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Hypertension: a systemic key to understanding local keloid severity
Author(s) -
Arima Juri,
Huang Chenyu,
Rosner Bernard,
Akaishi Satoshi,
Ogawa Rei
Publication year - 2015
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12277
Subject(s) - keloid , medicine , logistic regression , epidemiology , blood pressure , retrospective cohort study , population , dermatology , surgery , environmental health
This study assessed whether hypertension, a circulating factor, influences local keloid severity. This retrospective cross‐sectional study involved 304 consecutive patients (13–78 years old) with keloids who were surgically treated in our hospital between January 2011 and August 2013. Their blood pressure (BP), age and gender, and the size and number of their keloids before surgery were recorded. Ordinal logistic regression analyses showed that BP associated significantly with both keloid size and number (all p < 0.0001). Age also associated with keloid size ( p < 0.0001). However, a Goodness‐of‐fit chi‐square test showed that the prevalence of hypertension was not higher among keloid patients than in the general Japanese population. This study provides epidemiological evidence for the possibility that primary hypertension may aggravate keloids. We propose that the skin, along with the heart and liver, is a target organ of hypertension. The observations of this study, which require validation with large‐scale prospective interventional trials, suggest that keloid patients should be screened for hypertension and that antihypertensive treatments may be of prophylactic and therapeutic value for skin fibrosis.