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Effects of saliva on early post–tooth extraction tissue repair in rats
Author(s) -
Mohn Claudia E.,
Steimetz Tammy,
Surkin Pablo N.,
FernandezSolari Javier,
Elverdin Juan C.,
Guglielmotti María B.
Publication year - 2015
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12271
Subject(s) - granulation tissue , saliva , wound healing , inflammation , nitric oxide , medicine , connective tissue , tumor necrosis factor alpha , prostaglandin e2 , pathology , dentistry , surgery
The aim of the present study was to perform a biochemical, histological, and histomorphometrical evaluation of the mechanisms involved in tissue repair in rats subjected to submandibulectomy‐induced hyposialia, 24, 48, and 72 hours of post–tooth extraction. We studied the correlation between the lack of submandibular saliva and the modulation of inflammatory mediators involved in tissue repair, such as prostaglandin E 2 , nitric oxide (NO), and tumor necrosis factor alpha (TNF‐α). Rats with hyposialia showed a delay in socket healing, slow replacement of the clot with granulation tissue, and fewer cells and collagen fibers, concomitant with a longer inflammatory process, as compared to controls. The lack of saliva induced by submandibulectomy modified the levels of prostaglandin E 2 , NO, and TNF‐α, and tissue response in the early stages of wound healing compared to controls, and could thus determine alterations in later osteogenic response. Our results allow concluding that hyposialia modulates the parameters of inflammation studied here, and that it is essential for optimal healing. Therefore, these findings provide evidence for the importance of submandibular saliva to final bone socket healing.