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Simultaneous irrigation and negative pressure wound therapy enhances wound healing and reduces wound bioburden in a porcine model
Author(s) -
Davis Kathryn,
Bills Jessica,
Barker Jenny,
Kim Paul,
Lavery Lawrence
Publication year - 2013
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12104
Subject(s) - bioburden , negative pressure wound therapy , medicine , saline , wound healing , surgery , anesthesia , pathology , alternative medicine
Infected foot wounds are one of the most common reasons for hospitalization and amputation among persons with diabetes. The objective of the study was to investigate a new wound therapy system that employs negative pressure wound therapy ( NPWT ) with simultaneous irrigation therapy. For this study, we used a porcine model with full‐thickness excisional wounds, inoculated with P seudomonas aeruginosa. Wounds were treated for 21 days of therapy with either NPWT , NPWT with simultaneous irrigation therapy using normal saline or polyhexanide biguanide ( PHMB ) at low or high flow rates, or control. Data show that NPWT with either irrigation condition improved wound healing rates over control‐treated wounds, yet did not differ from NPWT alone. NPWT improved bioburden over control‐treated wounds. NPWT with simultaneous irrigation further reduced bioburden over control and NPWT ‐treated wounds; however, flow rate did not affect these outcomes. Together, these data show that NPWT with simultaneous irrigation therapy with either normal saline or PHMB has a positive effect on bioburden in a porcine model, which may translate clinically to improved wound healing outcomes.