Premium
Role of neuropeptides, neurotrophins, and neurohormones in skin wound healing
Author(s) -
Chéret Jérémy,
Lebonvallet Nicolas,
Carré JeanLuc,
Misery Laurent,
Le GallIanotto Christelle
Publication year - 2013
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12101
Subject(s) - neurohormones , neurotrophin , wound healing , neuropeptide , neuroscience , biology , receptor , peripheral nervous system , nervous system , sensory system , microbiology and biotechnology , central nervous system , endocrinology , immunology , biochemistry , hormone
Abstract Due to the close interactions between the skin and peripheral nervous system, there is increasing evidence that the cutaneous innervation is an important modulator of the normal wound healing process. The communication between sensory neurons and skin cells involves a variety of molecules (neuropeptides, neurohormones, and neurotrophins) and their specific receptors expressed by both neuronal and nonneuronal skin cells. It is well established that neurotransmitters and nerve growth factors released in skin have immunoregulatory roles and can exert mitogenic actions; they could also influence the functions of the different skin cell types during the wound healing process.