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How mechanical deformations contribute to the effectiveness of negative‐pressure wound therapy
Author(s) -
Daigle Patrick,
Despatis MarcAntoine,
Grenier Guillaume
Publication year - 2013
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1111/wrr.12052
Subject(s) - negative pressure wound therapy , wound healing , medicine , myofibroblast , wound care , intensive care medicine , action (physics) , surgery , pathology , fibrosis , physics , alternative medicine , quantum mechanics
Abstract Negative‐pressure wound therapy ( NPWT ) has significantly improved healing rates and patient comfort since its inception. However, a considerable number of questions have been raised regarding its mechanisms of action. Many health care workers and researchers have attempted to clarify the role of NPWT in wound healing. The purpose of this perspective article is to assemble some of the concepts that have been put forward in order to propose an integrated view of the mechanisms involved in NPWT . Particular emphasis will be placed on mechanically induced tissue deformations and their involvement in some of the key processes of wound healing, including nutrient and oxygen transport, blood vessel formation, and cellular proliferation and differentiation, mainly of myofibroblasts.