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Mechanical properties of canine osteosarcoma‐affected antebrachia
Author(s) -
Steffey Michele A.,
Garcia Tanya C.,
Daniel Leticia,
Zwingenberger Allison L.,
Stover Susan M.
Publication year - 2017
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/vsu.12628
Subject(s) - medicine , diaphysis , metaphysis , osteosarcoma , weight bearing , population , anatomy , pathology , surgery , orthopedic surgery , environmental health
Abstract Objective To determine the influence of neoplasia on the biomechanical properties of canine antebrachia. Study design Ex vivo biomechanical study. Sample population : Osteosarcoma (OSA)‐affected canine antebrachia (n = 12) and unaffected canine antebrachia (n = 9). Methods Antebrachia were compressed in axial loading until failure. A load‐deformation curve was used to acquire the structural mechanical properties of neoplastic and unaffected specimens. Structural properties and properties normalized by body weight (BW) and radius length were compared using analysis of variance (ANOVA). Modes of failure were compared descriptively. Results Neoplastic antebrachia fractured at, or adjacent to, the OSA in the distal radial diaphysis. Unaffected antebrachia failed via mid‐diaphyseal radial fractures with a transverse cranial component and an oblique caudal component. Structural mechanical properties were more variable in neoplastic antebrachia than unaffected antebrachia, which was partially attributable to differences in bone geometry related to dog size. When normalized by dog BW and radial length, strength, stiffness, and energy to yield and failure, were lower in neoplastic antebrachia than in unaffected antebrachia. Conclusions OSA of the distal radial metaphysis in dogs presented for limb amputation markedly compromises the structural integrity of affected antebrachia. However, biomechanical properties of affected bones was sufficient for weight‐bearing, as none of the neoplastic antebrachia fractured before amputation. The behavior of tumor invaded bone under cyclic loading warrants further investigations to evaluate the viability of in situ therapies for bone tumors in dogs.