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Outcomes and prognostic factors of surgical treatments for brachycephalic obstructive airway syndrome in 3 breeds
Author(s) -
Liu NaiChieh,
Oechtering Gerhard U.,
Adams Vicki J.,
Kalmar Lajos,
Sargan David R.,
Ladlow Jane F.
Publication year - 2017
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/vsu.12608
Subject(s) - medicine , confidence interval , odds ratio , logistic regression , receiver operating characteristic , airway , multivariate analysis , surgery , airway obstruction
Objective To determine prognostic indicators for the surgical treatment of brachycephalic obstructive airway syndrome (BOAS) and to compare the prognosis of 2 multilevel surgical procedures. Study Design Prospective clinical study. Sample Population Client‐owned pugs, French bulldogs, and bulldogs (n = 50). Methods Noninvasive whole‐body barometric plethysmography (WBBP) was used to assess respiratory function before, 1 month and 6 months after upper airway corrective surgery. Postoperatively, BOAS indices (ie, ascending severity score generated from WBBP data, 0%‐100%) that equaled to or exceeded the cut‐off values of BOAS in the diagnostic models were considered to have a “poor prognosis.” A multivariate logistic regression was used to assess predictors for prognosis. Results The median BOAS indices decreased after surgery (from 76% to 63%, P < .0001), although dogs with indices in this range would still be considered clinically affected. Age (odds ratios [OR] = 0.96, 95% confidence interval [CI]: 0.93‐0.99, P < .05), body condition (OR = 0.06, 95% CI: 0.01‐0.39, P < .01), laryngeal collapse (OR = 6.1, 95% CI: 1‐37.22, P < .05), and surgical techniques (OR = 7.94, 95% CI: 1.17‐54.01, P < .05) were associated with postoperative prognosis. The multivariate model suggests modified multilevel surgery (MMS) may have a better outcome than traditional multilevel surgery (TMS) ( P = .034). The positive predictive value of the logistic model was 84% (95% CI: 68‐94%) and the area under the receiver operating characteristic (ROC) curve was 89% (95% CI: 78‐99%, P <.0001). Conclusions Younger age, normal body condition, presence of laryngeal collapse, and treatment with TMS were negative prognostic factors after surgical treatment of BOAS. MMS is recommended, particularly in dogs with a higher probability of poor prognosis.