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Assessment of 3 Bowel Preparation Protocols for Computed Tomography Pneumocolonography in Normal Dogs
Author(s) -
Steffey Michele A.,
Zwingenberger Allison L.,
Daniel Leticia,
Taylor Sandra L.
Publication year - 2016
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/vsu.12524
Subject(s) - medicine , iopamidol , bowel preparation , iodinated contrast , crossover study , feces , computed tomography , protocol (science) , lumen (anatomy) , residual , nuclear medicine , radiology , algorithm , pathology , colonoscopy , contrast medium , colorectal cancer , mathematics , paleontology , alternative medicine , cancer , biology , placebo
Objective To investigate the effects of 3 different bowel preparation protocols on interpretation of computed tomography (CT) pneumocolonography images. Study Design Experimental crossover design. Animals Intact male, hound‐cross, research colony dogs (n=4). Methods All dogs received the 3 different bowel preparation protocols for CT pneumocolonography in the same order, with a minimum of 2 weeks between protocols. For each segment of large bowel, the subjective adequacy of bowel cleansing was assessed, residual fecal and bowel volumes were calculated, and the density of fecal material in the bowel lumen was measured. Linear mixed effect models that included a random dog effect were used to evaluate mean differences in outcome measures across protocols. Results No dogs experienced any clinical problems associated with the protocols or CT pneumocolonography. Bowel cleansing was considered adequate for CT pneumocolonography interpretation for all 3 protocols. There was a significant effect of protocol on residual fecal volumes and the fecal:bowel volume ratio, with the 2 protocols that included an extended fast producing the lowest total residual fecal volumes. There was a significant effect of protocol on maximum measured density of residual fecal material with the 2 protocols including iodinated contrast having the highest density. Conclusions All protocols were sufficient for CT pneumocolonography interpretation and contrast‐tagging of residual fecal material was successful with oral iopamidol administration. An at‐home bowel cleansing protocol may provide adequate bowel cleansing for CT pneumocolonography image interpretation.