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Microscopic Evaluation of Peritumoral Lesions of Feline Injection Site Sarcomas Identified by Magnetic Resonance Imaging and Computed Tomography
Author(s) -
Nemanic Sarah,
Milovancev Milan,
Terry Jesse L.,
StiegerVanegas Susanne M.,
Löhr Christiane V.
Publication year - 2016
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/vsu.12448
Subject(s) - medicine , magnetic resonance imaging , radiology , fiducial marker , cats , pathology , computed tomography , nuclear medicine
Objective Determine whether dual‐phase computed tomography angiogram (CTA) or magnetic resonance imaging (MRI) detect more peritumoral lesions of feline injection site sarcoma (FISS) and determine whether CTA or MRI imaging characteristics of peritumoral lesions correspond with microscopic findings. Study Design Prospective clinical study. Animals Ten client‐owned cats with FISS. Methods A fiducial marker detectable on CTA and MRI was sutured to the skin over the FISS as a standard reference point. All cats received MRI and CTA of the FISS, immediately followed by wide surgical excision. Targeted microscopic evaluation was performed on tissue with imaging‐identified lesions and on the surgical margins. Results A total of 87 imaging‐identified peritumoral lesions were examined microscopically (median 4 per cat, range 3–9) with 17/87 (20%) categorized as neoplastic, 51/87 (59%) as nonneoplastic, and 19/87 (22%) as equivocal. In 25 instances, peritumoral lesions were seen on both imaging modalities at the same location. Unique imaging characteristics were seen in 5/17 neoplastic peritumoral lesions (4 cats; all different lesions; 1 CTA, 4 MRI). The CTA and MRI appearances of the remaining 12/17 neoplastic lesions were nonspecific, being observed across more than 1 microscopic category. Conclusion CTA and MRI identified a similar number of peritumoral lesions. The extensive overlap between imaging features of neoplastic and nonneoplastic lesions precludes definitive identification of neoplastic peritumoral FISS lesions using CTA or MRI.