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Evaluation of Osteogenic Potentials of Avian Demineralized Bone Matrix in the Healing of Osseous Defects in Pigeons
Author(s) -
Sanaei Reza,
Abu Jalila,
Nazari Mojgan,
Zuki Mohd A. B.,
Allaudin Zeenathul N.
Publication year - 2015
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/vsu.12292
Subject(s) - dbm , demineralized bone matrix , medicine , bone healing , implant , radiography , matrix (chemical analysis) , histology , bone matrix , biocompatible material , dentistry , surgery , biomedical engineering , anatomy , pathology , materials science , amplifier , cartilage , optoelectronics , cmos , composite material
Objectives To evaluate avian allogeneic demineralized bone matrix (DBM) in the healing of long bone defects as a function of geometry and time in a pigeon model. Study Design Experimental. Animals Adult rock pigeons (n = 60). Methods Midshaft ulnar osseous defects were grafted with 2 geometric forms of DBM (tubular vs. chipped) and stabilized with a hybrid fixator. Autologous chips of sternal keel were used in a third group as control. Outcomes were evaluated by radiography and histology/histomorphometry at 4, 8, 12, and 24 weeks postoperatively. Results Despite an early rapid healing response, autografts plateaued (histologic score and new bone area) by 8 weeks with no significant improvement afterwards. Conversely, allogeneic DBM implants demonstrated continuous temporal improvement in bone healing, and tubular DBM finally outpaced autograft implants after week 12 with values for metrics achieving statistical significance by week 24. Chip DBM was inferior to tubular DBM and autograft. Conclusions Avian DBM is osteogenic, biocompatible, and safe in orthotopic sites with potential usefulness in avian bone grafting. Implant geometry (shape and size) affects such osteogenic potentials.