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Consensus recommendations on standardized magnetic resonance imaging protocols for multicenter canine brain tumor clinical trials
Author(s) -
Packer Rebecca A.,
Rossmeisl John H.,
Kent Michael S.,
Griffin John F.,
Mazcko Christina,
LeBlanc Amy K.
Publication year - 2018
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/vru.12608
Subject(s) - medicine , diffusion mri , magnetic resonance imaging , clinical trial , medical physics , neuroimaging , brain tumor , nuclear medicine , radiology , pathology , psychiatry
The National Cancer Institute Comparative Brain Tumor Consortium, Patient Outcomes Working Group, propose a consensus document in support of standardized magnetic resonance imaging protocols for canine brain tumor clinical trials. The intent of this manuscript is to address the widely acknowledged need to ensure canine brain tumor imaging protocols are relevant and have sufficient equivalency to translate to human studies such that: (1) multi‐institutional studies can be performed with minimal inter‐institutional variation, and (2) imaging protocols are consistent with human consensus recommendations to permit reliable translation of imaging data to human clinical trials. Consensus recommendations include pre‐ and postcontrast three‐dimensional T1‐weighted images, T2‐weighted turbo spin echo in all three planes, T2*‐weighted gradient recalled echo, T2‐weighted fluid attenuated inversion recovery, and diffusion weighted imaging/diffusion tensor imaging in transverse plane; field of view of ≤150 mm; slice thickness of ≤2 mm, matrix ≥ 256 for two‐dimensional images, and 150 or 256 for three‐dimensional images.