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VALIDATION OF DELAYED GADOLINIUM‐ENHANCED MAGNETIC RESONANCE IMAGING OF CARTILAGE AND T 2 MAPPING FOR QUANTIFYING DISTAL METACARPUS/METATARSUS CARTILAGE THICKNESS IN T HOROUGHBRED RACEHORSES
Author(s) -
Carstens Ann,
Kirberger Robert M.,
Dahlberg Leif E.,
Prozesky Leon,
Fletcher Lizelle,
Lammentausta Eveliina
Publication year - 2012
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/vru.12002
Subject(s) - cartilage , metacarpus , medicine , magnetic resonance imaging , anatomy , phalanx , proximal phalanx , articular cartilage , cadaver , osteoarthritis , nuclear medicine , pathology , radiology , alternative medicine
The purpose of this study was to determine whether delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (d GEMRIC ) and T 2 mapping are accurate techniques for measuring cartilage thickness in the metacarpus3/metatarsus3 ( M c3/ M t3) of T horoughbred racehorses. Twenty‐four M c3/ M t3 cadaver specimens were acquired from six healthy racehorses. Cartilage thickness was measured from postintra‐articular G d‐ DTPA 2− images acquired using short tau inversion recovery ( STIR ), and proton density weighted ( PD w) sequences, and compared with cartilage thickness measured from corresponding histologic images. Two observers performed each histologic measurement twice at three different sites, with measurement times spaced at least 5 days apart. Histologic cartilage thickness was measured at each of the three sites from the articular surface to the bone–cartilage interface, and from the articular surface to the mineralized cartilage interface (tidemark ) . Intra‐observer repeatability was good to moderate for d GEMRIC where M c3/ M t3 cartilage was not in contact with the proximal phalanx. Where the M c3/ M t3 cartilage was in contact with the proximal phalanx cartilage, d GEMRIC STIR and T 2 mapping PD w cartilage thicknesses of M c3/ M t3 could not be measured reliably. When measured from the articular surface to the bone–cartilage interface, histologic cartilage thickness did not differ from STIR or PD w cartilage thickness at the site where the M c3/ M t3 cartilage surface was separated from the proximal phalanx cartilage ( P > 0.05). Findings indicated that d GEMRIC STIR and T 2 mapping PD w are accurate techniques for measuring M c3/ M t3 cartilage thickness at locations where the cartilage is not in direct contact with the proximal phalanx cartilage.