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The incremental benefit of anaerobic culture for controlling bacterial risk in platelets: a systematic review and meta‐analysis
Author(s) -
Corean Jessica,
White Sandra K.,
Schmidt Robert L.,
Walker Brandon S.,
Fisher Mark A.,
Metcalf Ryan A.
Publication year - 2021
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.13013
Subject(s) - anaerobic exercise , propionibacterium , medicine , platelet , context (archaeology) , platelet transfusion , meta analysis , contamination , blood culture , surgery , immunology , biology , microbiology and biotechnology , bacteria , antibiotics , physiology , paleontology , ecology , genetics
Background and objectives Septic transfusion reactions are a principal cause of transfusion‐related mortality. The frequency of detectable bacterial contamination is greater in platelets compared to other blood components because platelets are stored at room temperature. Most strategies outlined in the September 2019 FDA guidance require both aerobic culture (AC) and anaerobic culture (AnC) testing. We performed a systematic review and meta‐analysis in an effort to provide the best available estimate of the effectiveness of AnC. Materials and methods Our analysis was performed according to published guidelines. Broad and context‐specific meta‐analyses of bacterial detection rates in platelets by AnC were performed to assess the practical effectiveness of AnC as a risk control measure. Results Seven studies with a total of 1 767 014 tested platelet components were included for analysis. With exclusion of positives due to Cutibacterium/Propionibacterium species and redundancy due to AC results, AnC detected 0·06 contamination events per thousand (EPT) components tested, twofold lower than the AC (0·12 EPT). Conclusion Excluding Cutibacterium/Propionibacterium species, AnC detects occasional bacterial contamination events that are not detected by AC (~1 in 17 000 platelet components).