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Prior blood donations do not affect efficacy of G‐ CSF mobilization nor outcomes of haematopoietic stem cell collection in healthy donors
Author(s) -
Pruszczyk Katarzyna,
Bartnik Krzysztof,
Bogusz Krzysztof,
Farhan Roiya,
Cwil Dominika,
Jastrzębska Aleksandra,
Moskowicz Albert,
Płachta Milena,
Chmiel Adam,
Skwierawska Kamila,
Urbanowska Elżbieta,
Jędrzejczak Wiesław Wiktor,
Snarski Emilian
Publication year - 2019
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12816
Subject(s) - apheresis , mobilization , haematopoiesis , medicine , hematology , granulocyte colony stimulating factor , stem cell , donation , blood donor , volunteer , immunology , progenitor cell , white blood cell , platelet , biology , chemotherapy , genetics , archaeology , economics , history , economic growth , agronomy
Background and Objectives Many consider volunteer blood donors as ideal candidates for unrelated haematopoietic progenitor cell ( HPC ) donation. However, frequent blood donations could influence the results of HPC mobilization. To our best knowledge, there are no data on the possible impact of repeated blood donation on efficiency of subsequent HPC mobilization by granulocyte colony‐stimulating factor (G‐ CSF ). Materials and Methods We compared outcomes of HPC mobilization in unrelated donors with and without a history of blood donation. We conducted a prospective study on 287 consecutive donors admitted to the Department of Hematology since January 2016. The final analysis included 153 donors who agreed to take part in the study and had undergone stem cell mobilization with G‐ CSF . Results History of blood donations prior to haematopoietic stem cell mobilization with G‐ CSF does not have a significant impact on the number of collected CD 34+ cells in the first leucocytapheresis (516.2 x 10 6 (170–1148) in blood donors vs 490.5 x 10 6 (101–1154) in non‐donors) ( P = 0.32). In all donors, in this study mobilization of HPC was successful: 87.5% of blood donors and 85.6% of non‐donors collected the required cell number in a single apheresis. In blood donors, a higher number of blood donations within 2 and 5 years prior to HPC mobilization correlated significantly with successful donation within one leucocytapheresis ( P = 0.014 and P = 0.024, respectively). Conclusion Multiple blood donations do not significantly influence the outcome of HPC collection in unrelated donors. Blood donors and non‐donors have similar results of HPC collection, so there is no reason to favour either group.