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Dose‐dependent effect of stored‐blood transfusions on recipient red blood cell indices, deformability and density
Author(s) -
Ichikawa Junko,
Koshino Ichiro,
Komori Makiko
Publication year - 2019
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12742
Subject(s) - mean corpuscular volume , red blood cell , erythrocyte deformability , microcirculation , medicine , red cell , erythrocyte aggregation , blood flow , blood cell , anesthesia , hemodynamics , surgery , cardiology , hematocrit
We prospectively studied the dose‐dependent effect of transfused stored red blood cells ( RBC s) on recipient RBC indices, deformability and cell density in 10 patients administered stored RBC s for blood transfusion during general surgery. There were dose‐dependent decreases in mean corpuscular volume and increases in mean corpuscular haemoglobin concentration after completion of 4‐ and 6‐unit stored RBC transfusions. The amount of dense populations increased proportionately with the amount of stored RBC s transfused. The maximal deformability index value was significantly and dose‐dependently decreased, suggesting that hemodynamic blood flow, especially the microcirculation may be impaired in patients who receive large amounts of stored RBC s.