A novel c.166A>T (p.Thr56Ser) mutation in   GYPB *S  accounting for unusual S antigen expression | Zendy

Suzuki Yumi | Zendy; Isa Kazumi | Zendy; Ogasawara Kenichi | Zendy; Kikuchi Yuika | Zendy; Yabe Ryuichi | Zendy; Tsuno NelsonHirokazu | Zendy; Uchikawa Makoto | Zendy; Satake Masahiro | Zendy

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A novel c.166A>T (p.Thr56Ser) mutation in GYPB *S accounting for unusual S antigen expression

Author(s) -

Suzuki Yumi,

Isa Kazumi,

Ogasawara Kenichi,

Kikuchi Yuika,

Yabe Ryuichi,

Tsuno NelsonHirokazu,

Uchikawa Makoto,

Satake Masahiro

Publication year - 2019

Publication title -

vox sanguinis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.68

H-Index - 83

eISSN - 1423-0410

pISSN - 0042-9007

DOI - 10.1111/vox.12737

Subject(s) - polyclonal antibodies , proband , antigen , microbiology and biotechnology , monoclonal antibody , antibody , sanger sequencing , cloning (programming) , mutation , exon , monoclonal , biology , chemistry , immunology , genetics , gene , computer science , programming language

We found an individual with weakened S antigen expression on red blood cells ( RBC s) during routine blood grouping. The proband was typed S+s+ by polyclonal antibodies, but the RBC s demonstrated different reactivity with three monoclonal anti‐S. The proband did not have alloanti‐S. Cloning and Sanger sequencing revealed that the proband had a c.166A>T (p.Thr56Ser) mutation in exon 4 of GYPB * S . When antibody screening of 60 455 blood donors was performed using the proband RBC s, no antibodies were detected. GYPB *S with c.166T should encode an unusual S antigen but the creation of a novel antigen remains to be investigated.

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