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Prolonged platelet storage associated with increased frequency of transfusion‐related adverse events
Author(s) -
Losos M.,
Biller E.,
Li J.,
Blower L.,
Hamad D.,
Patel G.,
Scrape S.,
Cataland S.,
Chen J.
Publication year - 2018
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12622
Subject(s) - apheresis , platelet , medicine , adverse effect , blood transfusion , plateletpheresis , logistic regression , univariate analysis , retrospective cohort study , platelet transfusion , gastroenterology , multivariate analysis , immunology
Background Platelets ( PLT s) have been associated with the highest rate of transfusion‐associated adverse events ( AE s) among all blood products. Most of PLT ‐associated AE s are considered to have an inflammatory mechanism. However, it is still unclear whether prolonged storage of platelets is associated with an increased rate of transfusion‐related AE s, especially in the era of universal prestorage leucoreduction. Methods/Materials In this retrospective study, 52 649 PLT products consisting of about 80% apheresis PLT s and 20% whole blood‐derived ( WBD ) PLT s were transfused to 9415 patients from July 2011 to March 2017. All the PLT s were leucoreduced prior to storage. All but 69 units of the apheresis PLT s were irradiated and none of WBD PLT s were irradiated. During this period, a total of 284 AE s that were reported to the transfusion service were analysed. Results Univariate and multivariate logistic analyses showed that apheresis/irradiated PLT s and PLT age were associated with a significantly increased frequency of inflammation type AE s ( OR (95% CI ): 2·24 (1·32, 4·15) and 1·30 (1·12, 1·52), respectively). There was a significant increase in the frequency of inflammation AE s associated with prolonged storage of apheresis/irradiated PLT s [ OR (95% CI ): 1·26 (1·03, 1·53)]. In contrast, there was no association between allergic symptoms and PLT age. Moreover, the frequency of transfusion AE s associated with apheresis/irradiated PLT s (57·2/10 000) was significantly higher than that of WBD /nonirradiated PLT s (26·0/10 000) ( P < 0·01). Conclusion Prolonged storage of apheresis/irradiated PLT s was associated with a higher frequency of inflammation AE s. Apheresis/irradiated PLT s caused more AE s than WBD /nonirradiated PLT s.