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Prospective quality control study of a novel gravity‐driven whole blood separation system suitable for humanitarian crises
Author(s) -
Hackstein H.,
Möller A.,
Gerlach M.,
Sachs U.,
Bein G.
Publication year - 2017
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12595
Subject(s) - haemolysis , centrifugation , whole blood , hematocrit , chromatography , chemistry , medicine , andrology , immunology
Centrifugation‐based whole blood ( WB ) separation represents the worldwide standard but it depends on electricity and infrastructure. We have prospectively evaluated a novel hollow‐fibre WB separation system that does not require manual priming or blood flow regulation ( n = 29). RBC units contained sufficient Hb (50·4 g ± 4·3), low leucocytes (90 000 ± 0·008), exhibited low haemolysis (0·57% ± 0·49) and robust ATP content (51·47% ± 8·2) after 43 days storage. Plasma units contained low leucocytes and mean coagulation factor activities for FV , FVIII and FXI were 47%, 90% and 68%, respectively. RBC met quality specifications but plasma units exhibited reduced FV and FXI activity.