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Prothrombin complex concentrate for emergent reversal of warfarin: an international survey of hospital protocols
Author(s) -
Gorlin J.,
Kinney S.,
Fung M. K.,
Tinmouth A.
Publication year - 2017
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12539
Subject(s) - prothrombin complex concentrate , warfarin , dosing , medicine , prothrombin complex , excellence , intensive care medicine , pharmacology , coagulation , political science , law , atrial fibrillation
For emergent warfarin reversal, four‐factor prothrombin complex concentrates (4 FPCC s) are recommended by many international guidelines. We surveyed international clinical sites including members of the Biomedical Excellence for Safer Transfusion ( BEST ) Collaborative. Most sites have emergent warfarin reversal protocols (53% use PCC , 25% use PCC + plasma and 2% use plasma alone); however, variation between adjusted dosing and fixed dosing was observed.