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Bacteria can proliferate in thawed cryoprecipitate stored at room temperature for longer than 4 h
Author(s) -
RamirezArcos S.,
Jenkins C.,
Sheffield W. P.
Publication year - 2017
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12517
Subject(s) - cryoprecipitate , microbiology and biotechnology , staphylococcus epidermidis , serratia , pseudomonas putida , pseudomonas aeruginosa , bacteria , chemistry , food science , biology , staphylococcus aureus , pseudomonas , immunology , genetics , platelet
Although key coagulation factor activities are maintained in thawed cryoprecipitate stored for up to 24 h at ambient temperature, several jurisdictions limit such storage to 4–6 h. Here, we separately spiked thawed cryoprecipitate units with four bacterial strains: Staphylococcus epidermidis , Serratia liquefaciens , Pseudomonas putida and Pseudomonas aeruginosa . No strains grew in the first 4 h of storage, but by 24 h, three of four exhibited up to 1000‐fold proliferation. Pathogen inactivation technologies could be explored to mitigate the safety risk posed by extending storage of thawed cryoprecipitate at room temperature.