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Growth differentiation factor 11 ( GDF 11) – a promising anti‐ageing factor – is highly concentrated in platelets
Author(s) -
Bueno J. L.,
Ynigo M.,
Miguel C.,
GonzaloDaganzo R. M.,
Richart A.,
Vilches C.,
Regidor C.,
GarcíaMarco J. A.,
FloresBallester E.,
Cabrera J. R.
Publication year - 2016
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12438
Subject(s) - platelet , gdf15 , ageing , immunology , growth factor , andrology , plateletpheresis , biology , medicine , chemistry , endocrinology , apheresis , receptor
Recent research suggests that growth differentiation factor 11 ( GDF 11) could reverse age‐related diseases and that its blood concentration decreases with age. This poses plasma from young donors as a therapeutic GDF 11 source to treat age‐related diseases. In addition, the tissue source of circulating GDF 11 remains unknown. We analysed GDF 11 levels in paired samples of serum, plasma and platelet lysate ( PL ) from 23 volunteers. Plasma and PL were collected by plateletpheresis. Here, we show that GDF 11 is highly concentrated in platelets and that the circulating levels reported in previous studies could be biased as a result of serum sample manipulation.