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Case–control study of immediate and delayed vasovagal reactions in blood donors
Author(s) -
Narbey D.,
Fillet A.M.,
Jbilou S.,
Tiberghien P.,
Djoudi R.
Publication year - 2016
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12418
Subject(s) - medicine , body mass index , underweight , donation , phlebotomy , multivariate analysis , overweight , blood donor , blood transfusion , surgery , pediatrics , immunology , economics , economic growth
Background and objective(s) Vasovagal reactions ( VVR s) are the most common adverse events associated with blood donations. To assess the relative importance of VVR risk factors, a retrospective case–control study of severe immediate and delayed VVR s was performed. Study design Vasovagal reactions were defined as immediate when occurring at the transfusion site and as delayed when occurring outside the transfusion site and within 24 h following donation. VVR s with probable or certain imputability and moderate to death severity were considered. One control/case was drawn randomly from among donors without VVR . Explanatory variables (sex, age, body mass index ( BMI ), donation status, type of phlebotomy) as well as the matching variables (donation region, date) and the interaction term (sex and BMI ) were integrated into the multivariate model. Results In French hemovigilance data collected from 2011 to 2013, 8410 immediate and 833 delayed VVR s occurred among 8 834 214 donations. In multivariate analysis, occurrence of immediate VVR was strongly associated with first‐time donation ( OR 4·34; 95% CI : 3·93–4·79, P < 0·0001) and the 18–24 age group ( OR 2·24; 95% CI : 2·00–2·45, P < 0·0001) and of delayed VVR with women with a normal BMI ( OR 7·31; 95% CI : 4·96–10·77, P < 0·0001), overweight BMI ( OR 7·89; 95% CI : 4·84–12·87, P < 0·0001) or obese BMI ( OR 3·72; 95% CI : 1·42–9·74, P < 0·0001), and in men with an underweight BMI ( OR 6·39; 95% CI : 1·56–26·13, P < 0·0001). Apheresis was a risk factor for occurrence of both immediate and delayed VVR . Conclusion Our study highlights that first‐time donation by a young person is particularly at risk of immediate VVR while a female donor is at risk of delayed VVR .