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Increased coagulation and fibrinolytic potential of solvent–detergent plasma: a comparative study between Omniplasma and fresh frozen plasma
Author(s) -
Beers J. J. B. C.,
Egmond L. T.,
Wetzels R. J. H.,
Verhezen P. W. M.,
Beckers E. A. M.,
Oerle R.,
Spronk H. M. H.,
Straat R. J. M. H. E.,
Henskens Y. M. C.
Publication year - 2016
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12395
Subject(s) - fresh frozen plasma , coagulation , blood coagulation factors , plasma , chemistry , medicine , coagulation testing , chromatography , immunology , platelet , physics , quantum mechanics
Background and objectives In this study, differences in levels of proteins involved in coagulation and fibrinolysis were compared between fresh frozen (quarantine plasma) and Omniplasma. Furthermore, thawing conditions and plasma stability after thawing were studied. Materials and Methods 10 Omniplasma and 10 quarantine plasma units were used to study different procoagulation, anticoagulation and fibrinolytic parameters. Analysis took place at different time‐points during plasma storage at 2–6°C. Results At baseline, significant reduced levels of factor V, free protein S, α2‐antiplasmin and tPA ‐induced ROTEM lysis time were observed in Omniplasma as compared to quarantine plasma. Moreover, thrombin generation, IX a‐ AT complex levels and factor XI a were significantly increased in Omniplasma. The majority of the parameters studied remained stable in Omniplasma 48 h after thawing, with the exception of factor VIII (decrease) and IX a‐ AT (increase). Conclusion Our results suggest an increased coagulation potential, presumingly as a result of contact activation during the production process and also, an increased fibrinolytic potential in Omniplasma. The stability of Omniplasma, based upon the different parameters studied, is comparable to Q‐plasma. A maximum post‐thawing time of 48 hfor Omniplasma can be suggested.