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The impact of donor characteristics on the immune cell composition of second allografts in Chinese people
Author(s) -
Chen L.,
Chang YJ.,
Xu LP.,
Huang XJ.
Publication year - 2016
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12394
Subject(s) - platelet , immune system , immunology , medicine , t cell , transplantation , andrology , microbiology and biotechnology , biology
Background The association of the donor characteristics with the immune cell composition in second allografts remains poorly understood. In this study, we investigated retrospectively the effects of the donor characteristics on the immune cell composition in second allografts. Study design and methods The immune cell composition in second allografts of granulocyte colony‐stimulating factor (G‐ CSF ) mobilized peripheral blood harvests from 100 healthy donors (male, 47, female, 53; median age, 39 years old) who underwent a second‐time donation were correlated with their donor characteristics. Results The median counts of CD 3 + T cells, CD 4 + T cells, CD 8 + T cells, CD 3 + CD 4 − CD 8 − T cells and monocytes in allografts were 150·17 × 10 6 /kg, 82·57 × 10 6 /kg, 48·02 × 10 6 /kg and 24·97 × 10 6 /kg, respectively. Multivariate analysis showed that the number of lymphocytes and platelets pre‐first collection of G‐ CSF mobilized blood ( FM ) was strongly associated with the number of total lymphocytes (for lymphocytes, P = 0·003; for platelets, P = 0·012), CD 3 + T cells (for lymphocytes, P = 0·009; for platelets, P = 0·004) and CD 3 + CD 4 + T cells (for lymphocytes, P = 0·035; for platelets, P = 0·004) in the second allograft. The donor's BMI was negatively related to the number of CD 3 + T cells ( P = 0·022) and CD 3 + CD 4 + T cells ( P = 0·026) in the second allograft. The donor weight was negatively associated with the number of CD 3 + CD 4 − CD 8 − T cells ( P = 0·015) in the second allograft, while the pre‐ FM white blood cell count showed a positive correlation ( P = 0·009). Conclusion The results demonstrate the impact of the donor characteristics, including pre‐ FM platelet count and lymphocyte count, donor BMI and weight, on the immune cell composition in the second allograft.