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Rare and transient anti‐D antibody response in D − liver transplant recipients transfused with D + red blood cells
Author(s) -
Burin des Roziers N.,
Ibanez C.,
Samuel D.,
Francoz C.,
Idri S.,
François A.,
Mortelecque R.,
Bierling P.,
Pirenne F.
Publication year - 2016
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12392
Subject(s) - medicine , antibody , haemolysis , immunology , red blood cell , immune system , liver transplantation , antibody response , gastroenterology , isoantibodies , transplantation
A retrospective analysis was conducted on 20 D − liver transplant ( LT ) recipients transfused with D + RBC s perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti‐D detectable by the indirect antiglobulin test. Two patients produced weak anti‐D that reacted only with papain‐treated RBC s at 10 and 11 days without any sign of immune haemolysis. Antibodies became quickly undetectable. These data suggest an unusual pattern of alloimmunization in LT recipients with rapid, weak and transient antibody response and support the safety of transfusing D + RBC s in most of D − patients during LT surgery.