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Amotosalen‐ HC l‐ UVA pathogen reduction does not alter poststorage metabolism of soluble CD 40 ligand, Ox40 ligand and interkeukin‐27, the cytokines that generally associate with serious adverse events
Author(s) -
HamzehCognasse H.,
Laradi S.,
Osselaer J. C.,
Cognasse F.,
Garraud O.
Publication year - 2015
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12203
Subject(s) - platelet , chemistry , ligand (biochemistry) , cytokine , pathogen , immunology , biochemistry , medicine , receptor
Platelets in therapeutic platelet concentrates are commonly acknowledged to release biologically active constituents during storage. This study examined the influence of photochemical pathogen reduction treatment ( PRT ) using amotosalen‐ HCl and UVA light vs. untreated control platelet components, on three factors recently reported to be associated with serious adverse events associated with platelet component (PC) transfusions: sCD 40L, IL‐27 and sOX 40 ligand. Levels of such cytokine‐like factors increased significantly during storage, but no significant difference was detected between PRT ‐ and control PC s. This suggests that occurrences of AEs are not directly influenced by PRT but rather may depend on alternate determinants.