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Microchimerism in the transfused obstetric population
Author(s) -
Bloch E. M.,
Busch M. P.,
Lee T.H.,
Montalvo L.,
Matthews Y.,
Bird A.,
Bruhn R.,
Stefan V.
Publication year - 2014
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12177
Subject(s) - microchimerism , medicine , pregnancy , prospective cohort study , population , blood transfusion , obstetrics , cohort , cohort study , immunology , fetus , biology , genetics , environmental health
Microchimerism ( MC ), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion‐associated MC ( TA ‐ MC ) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high‐level TA ‐ MC . We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA ‐ MC ; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA ‐ MC does not occur in this population.