Microchimerism in the transfused obstetric population | Zendy

Bloch E. M. | Zendy; Busch M. P. | Zendy; Lee T.H. | Zendy; Montalvo L. | Zendy; Matthews Y. | Zendy; Bird A. | Zendy; Bruhn R. | Zendy; Stefan V. | Zendy

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Microchimerism in the transfused obstetric population

Author(s) -

Bloch E. M.,

Busch M. P.,

Lee T.H.,

Montalvo L.,

Matthews Y.,

Bird A.,

Bruhn R.,

Stefan V.

Publication year - 2014

Publication title -

vox sanguinis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.68

H-Index - 83

eISSN - 1423-0410

pISSN - 0042-9007

DOI - 10.1111/vox.12177

Subject(s) - microchimerism , medicine , pregnancy , prospective cohort study , population , blood transfusion , obstetrics , cohort , cohort study , immunology , fetus , biology , genetics , environmental health

Microchimerism ( MC ), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion‐associated MC ( TA ‐ MC ) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high‐level TA ‐ MC . We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA ‐ MC ; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA ‐ MC does not occur in this population.

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